Speakers - DPSWC2025

Abstract

Background: One of the greatest challenges in the progression of non surgical facial rejuvenation is developing new effective and safe treatments that can lead to natural long-term results in a minimally invasive way. The emerging field of Regenerative Aesthetic Medicine is responding to this request by proposing different autologous treatments such as platelet therapies, adipose derived stem cells, micro fat, nanofat, stromal vascular fraction. Recently we presented the first clinical results of a new concept for face and neck
rejuvenation: a combined use of stem cells and two laser technologies, the wavelength 1450 nm for micro coagulation and the wavelength 980 for stimulation the production of neo-collagen and elastin.
Objective: This new larger report verified the role of stem cells in the clinical improvement of treatment areas with this innovative protocol for non surgical rejuvenation of face and neck

Matherials and Methods: We treated two groups homogeneous of 350 patients with mild to moderate degrees of photo damage: group A received the standard protocol: 4 successive laser treatment with stem cells application at 3 weeks intervals group B (control) received only 4 successive laser treatments at 3 week intervals without stem cells application. Clinical improvement of treatment areas was determined in both groups Clinical improvement of treatment areas was determined Clinical improvement of treatment areas was determined in both groups at 1, 3 , 6, 12, 24 months follow up. At each time, skin elasticity measurements were performed using a cutometer and a specific skin software (FS 800 Scan System- Padova Italy) was used to evaluate wrinkles density, spot density, skin dark and light, spot density. Patient satisfaction surveys were also obtained at each follow up visit.

Results: In patients treated with stem cells and laser technologies a greater than 85% clinical improvement in photo damage at the 12 and 24 month follow up was achieved in nearly 95% of patients. All patients reported a statistically significant higher level of skin firmness and a statistically significant increase in skin elasticity, improvement of the texture of the skin and visible reduction of wrinkles with no side effects and with a very high patient satisfaction rate.In the control group of patients, treated without stem cells, clinical improvement in photodamage at the 12 month follow up was less of 35%, decreasing to 15% at 24 month follo up. All patients reported a lower increase in skin elasticity, texture of the skin and reduction of wrinkles, with a lower patient satisfaction rate.

Conclusions: This report confirmed the great effectiveness of this innovative method of non surgical facial rejuvenation and the key role of stem cells in the quality of the res.